التداخل بين دوكسيركالسيفيرول ومودافينيل

Examples Glutethimide and phenobarbital Intervention If a patient initiates or discontinues therapy with an enzyme inducer, dose adjustment of doxercalciferol may be necessary.

Enzyme inducers: Formation of the active doxercalciferol moiety may be affected and may necessitate dosage adjustment.

Enzyme Inducers Clinical Impact Doxercalciferol is activated by CYP 27 in the liver.

Enzyme inducers may affect the 25-hydroxylation of doxercalciferol [see Clinical Pharmacology ( 12.3 )].