التداخل بين إيفافيرينز وإسليكاربازيبين

CYP2C19 Substrates APTIOM can inhibit CYP2C19, which can cause increased plasma concentrations of drugs that are metabolized by this isoenzyme (e.g., phenytoin, clobazam, and omeprazole) [see Clinical Pharmacology ( 12.3 )].

Patients who are receiving concomitant anticonvulsant medications primarily metabolized by the liver, such as phenytoin and phenobarbital, may require periodic monitoring of plasma levels [see Drug Interactions ( 7.1 ) ] .

Anticonvulsants:Carbamazepine PhenytoinPhenobarbital ↓ carbamazepine * ↓ efavirenz * ↓ anticonvulsant ↓ efavirenz There are insufficient data to make a dose recommendation for efavirenz.

Potential for reduction in anticonvulsant and/or efavirenz plasma levels; periodic monitoring of anticonvulsant plasma levels should be conducted.

Alternative anticonvulsant treatment should be used.