التداخل بين إيفافيرينز وكيتوكونازول

Therefore, administration of potent enzyme inducers of CYP3A4 with ketoconazole tablets is not recommended.

Coadministration of ketoconazole tablets with potent enzyme inducers of CYP3A4 may decrease the bioavailability of ketoconazole to such an extent that efficacy may be reduced.

Antivirals: efavirenz, nevirapine.

Antifungals: Voriconazole Itraconazole Ketoconazole Posaconazole ↓ voriconazole * ↑ efavirenz * ↓ itraconazole * ↓ hydroxyitraconazole * ↓ ketoconazole ↓ posaconazole * Efavirenz and voriconazole should not be coadministered at standard doses.

Consider alternative antifungal treatment because no dose recommendation for ketoconazole can be made.

QT Prolonging Drugs There is limited information available on the potential for a pharmacodynamic interaction between efavirenz and drugs that prolong the QTc interval.

Consider alternative antifungal treatment because no dose recommendation for itraconazole can be made.