التداخل بين إيفافيرينز ولاميفودين وتينوفوفير وفيراباميل

CYP3A4 inducers decrease verapamil levels ( 7.1 )

Inducers of CYP3A4 (e.g., rifampin) have caused a lowering of plasma levels of verapamil.

Calcium channel blockers: Diltiazem ↓ diltiazem ↓ desacetyl diltiazem ↓ N-monodesmethyldiltiazem Diltiazem dose adjustments should be guided by clinical response (refer to the full prescribing information for diltiazem).

Others (e.g., felodipine, nicardipine, nifedipine, verapamil) ↓ calcium channel blocker When coadministered with EFV, dosage adjustment of calcium channel blocker may be needed and should be guided by clinical response (refer to the full prescribing information for the calcium channel blocker).