التداخل بين إنتاكابون وليفودوبا

…Metabolized By Catechol-O-Methyltransferase (COMT) When a single 400 mg dose of entacapone was given with intravenous isoprenaline (isoproterenol) and epinephrine without coadministered levodopa and dopa decarboxylase inhibitor, the overall mean maximal changes in heart rate during infusion were about 50% and 80% higher than with placebo, for isoprenaline and epinephrine,…

Falling Asleep During Activities of Daily Living and Somnolence Patients with Parkinson’s disease treated with Entacapone Tablets, which increases plasma levodopa levels, or with levodopa have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living (including the operation of motor vehicles).

Hormone Levels Levodopa is known to depress prolactin secretion and increase growth hormone levels.

Treatment with entacapone coadministered with levodopa and dopa decarboxylase inhibitor does not change these effects.

More than 600 patients with Parkinson’s disease in clinical studies have used selegiline in combination with entacapone and levodopa and dopa decarboxylase inhibitor.