التداخل بين إبليرينون وليثيوم

• Diuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.

Drugs Having Clinically Important Interactions with Lithium Table 4: Clinically Important Drug Interactions with Lithium Diuretics Clinical Impact: Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations .

Lithium toxicity has been reported in patients receiving lithium concomitantly with diuretics and ACE inhibitors.

Serum lithium levels should be monitored frequently if eplerenone is administered concomitantly with lithium.

Lithium A drug interaction study of eplerenone with lithium has not been conducted.