التداخل بين إرغوتامين وكافيين وميكسيليتين

Additionally, in one controlled study in five normal subjects and seven patients, the clearance of caffeine was decreased 50% following the administration of mexiletine.

Concurrent use of mexiletine and theophylline may lead to increased plasma theophylline levels.

One controlled study in eight normal subjects showed a 72% mean increase (range 35 to 136%) in plasma theophylline levels.

If mexiletine and theophylline are to be used concurrently, theophylline blood levels should be monitored, particularly when the mexiletine dose is changed.

An appropriate adjustment in theophylline dose should be considered.