التداخل بين فليكاينيد وبروبرانولول

Concomitant negative chronotropic therapy such as digoxin or beta-blockers may lower the risk of this complication.

In a study involving healthy subjects receiving flecainide acetate and propranolol concurrently, plasma flecainide levels were increased about 20% and propranolol levels were increased about 30% compared to control values.

In this formal interaction study, flecainide acetate and propranolol were each found to have negative inotropic effects; when the drugs were administered together, the effects were additive.

The effects of concomitant administration of flecainide acetate and propranolol on the PR interval were less than additive.

In flecainide acetate clinical trials, patients who were receiving beta blockers concurrently did not experience an increased incidence of side effects.