التداخل بين فلوكونازول وفلوفاستاتين

Steps to Prevent or Reduce the Risk of Myopathy and Rhabdomyolysis Avoid concomitant use of fluvastatin sodium extended-release tablets with gemfibrozil, cyclosporin, and fluconazole.

• Cyclosporine and Fluconazole : Avoid use with fluvastatin sodium extended-release tablets.

Intervention Avoid concomitant use of fluconazole with fluvastatin sodium extended-release tablets.

Fluconazole Clinical impact Fluconazole coadministration increases fluvastatin exposure.

The risk of myopathy and rhabdomyolysis may be increased with concomitant use of fluconazole with fluvastatin sodium extended-release tablets.

HMG-CoA reductase inhibitors The risk of myopathy and rhabdomyolysis increases when fluconazole is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin (decreased hepatic metabolism of the statin).

HMG-CoA reductase inhibitors should be discontinued if a marked increase in creatinine kinase is observed or myopathy/rhabdomyolysis is diagnosed or suspected.

Dose reduction of statins may be needed.

Refer to the statin-specific prescribing information for details.