التداخل بين فلوكونازول وريفامبيسين

…Prevention or Management: Perform prothrombin time daily or as frequently as necessary to establish and maintain the required dose of anticoagulant Warfarin Decrease exposure Antifungals Fluconazole Decrease AUC by 23% Itraconazole Prevention or Management: Not recommended 2 weeks before and during itraconazole treatment Decrease exposure Ketoconazole Decrease exposure…

(See CLINICAL PHARMACOLOGY: Drug Interaction Studies .) Rifampin Rifampin enhances the metabolism of concurrently administered fluconazole.

Depending on clinical circumstances, consideration should be given to increasing the dose of fluconazole when it is administered with rifampin.