التداخل بين فلوكونازول وتيربينافين

The influence of terbinafine on the pharmacokinetics of fluconazole, cotrimoxazole (trimethoprim and sulfamethoxazole), zidovudine or theophylline was not considered to be clinically significant.

Coadministration of a single dose of fluconazole (100 mg) with a single dose of terbinafine resulted in a 52% and 69% increase in terbinafine C max and AUC, respectively.

Drug interactions have also been noted with cimetidine, fluconazole, cyclosporine, rifampin, and caffeine.

Fluconazole is an inhibitor of CYP2C9 and CYP3A enzymes.