التداخل بين فلوفوكسامين وميكسيليتين

Mexiletine: Monitor serum mexiletine levels ( 5.8 ).

Mexiletine: The effect of steady-state fluvoxamine (50 mg b.i.d. for 7 days) on the single dose pharmacokinetics of mexiletine (200 mg) was evaluated in 6 healthy Japanese males.

The clearance of mexiletine was reduced by 38% following coadministration with fluvoxamine compared to mexiletine alone.

If fluvoxamine and mexiletine are coadministered, serum mexiletine levels should be monitored.

Mexiletine: See Warnings and Precautions ( 5.8 ) .

In a formal, single-dose interaction study (n = 6 males) the clearance of mexiletine was decreased by 38% following the coadministration of fluvoxamine, an inhibitor of CYP1A2.