التداخل بين فوندابارينوكس وفيتوميناديون (فيتامين ك1)

Do not administer agents that enhance the risk of hemorrhage with fondaparinux sodium unless essential for the management of the underlying condition, such as vitamin K antagonists for the treatment of VTE.

Anticoagulants Phytonadione injectable emulsion may induce temporary resistance to prothrombin-depressing anticoagulants, especially when larger doses of phytonadione injectable emulsion are used.

Should this occur, higher doses of anticoagulant therapy may be needed when resuming anticoagulant therapy, or a change in therapy to a different class of anticoagulant may be necessary (i.e., heparin sodium).

Anticoagulants: May induce temporary resistance to prothrombin-depressing anticoagulants.

Phytonadione injectable emulsion does not affect the anticoagulant action of heparin.