التداخل بين غانسيكلوفير وفالغانسيكلوفير

Valganciclovir tablets are contraindicated in patients who have had a demonstrated clinically significant hypersensitivity reaction (e.g., anaphylaxis) to valganciclovir, ganciclovir, or any component of the formulation [see Adverse Reactions (6.1) ].

Hypersensitivity to valganciclovir or ganciclovir.

Table 9 Established and Other Potentially Significant Drug Interactions with Ganciclovir Name of the Concomitant Drug Change in the Concentration of Ganciclovir or Concomitant Drug Clinical Comment Imipenem-cilastatin Unknown Coadministration with imipenem-cilastatin is not recommended because generalized seizures have been reported in patients who received ganciclovir…

( 2.5 , 5.2 , 8.5 , 8.6 ) 5.1 Hematologic Toxicity Severe leukopenia, neutropenia, anemia, thrombocytopenia, pancytopenia, and bone marrow failure including aplastic anemia have been reported in patients treated with valganciclovir hydrochloride or ganciclovir.

Increased monitoring for cytopenias may be warranted if therapy with oral ganciclovir is changed to valganciclovir hydrochloride because of increased plasma concentrations of ganciclovir after valganciclovir hydrochloride administration [see Clinical Pharmacology (12.3) ] .

Ganciclovir for Injection is contraindicated in patients who have experienced a clinically significant hypersensitivity reaction (e.g., anaphylaxis) to ganciclovir, valganciclovir, or any component of the formulation.

• Hypersensitivity to ganciclovir or valganciclovir.