التداخل بين غليميبيريد وميكونازول

• Miconazole: Severe hypoglycemia can occur when glimepiride tablets and oral miconazole are used concomitantly.

Miconazole A potential interaction between oral miconazole and sulfonylureas leading to severe hypoglycemia has been reported.

Whether this interaction also occurs with other dosage forms of miconazole is not known 7.3 Cytochrome P450 2C9 Interaction There may be an interaction between glimepiride and inhibitors (e.g., fluconazole) and inducers (e.g., rifampin) of cytochrome P450 2C9.

Although the systemic absorption of miconazole following ORAVIG administration is minimal and plasma concentrations of miconazole are substantially lower than when given intravenously, the potential for interaction with drugs metabolized through CYP2C9 and CYP3A4 such as oral hypoglycemics, phenytoin, or ergot alkaloids cannot be ruled out.