التداخل بين غوانفاسين وفينوباربيتال

Consider the potential for additive sedative effects with CNS depressant drugs.

…and its plasma concentrations can be significantly affected resulting in an increase in exposure Consider dose reduction [see Dosage and administration (2.7) ] Strong and moderate CYP3A4 inducers, e.g., rifampin, efavirenz Guanfacine is primarily metabolized by CYP3A4 and its plasma concentrations can be significantly affected resulting in a decrease in exposure…

Strong and moderate CYP3A4 inducers decrease guanfacine exposure.