التداخل بين هيدروكودون وكلورفينيرامين ونافسيلين

In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in hydrocodone plasma concentration.

Concomitant use with CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers) can result in a fatal overdose of hydrocodone.

Avoid the use of Hydrocodone Polistirex and Chlorpheniramine Polistirex in patients who are taking CYP3A4 inducers.

Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in Hydrocodone Polistirex and Chlorpheniramine Polistirex-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions.

Concomitant use of Hydrocodone Polistirex and Chlorpheniramine Polistirex with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could decrease hydrocodone plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal syndrome in a patient who had developed physical dependence to hydrocodone.