التداخل بين إندوميثاسين وتريبروستينيل

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.

In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation.

This effect has been attributed to NSAID inhibition of renal prostaglandin synthesis Intervention: During concomitant use of INDOCIN and lithium, monitor patients for signs of lithium toxicity.

This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis.