التداخل بين ليديباسفير وسوفوسبوفير ورانيتيدين

Concomitant Drug Class: Drug Name Effect on Concentration ↓ = decrease, ↑ = increase Clinical Comment tenofovir DF = tenofovir disoproxil fumarate Acid Reducing Agents: ↓ ledipasvir Ledipasvir solubility decreases as pH increases.

(e.g., famotidine) H 2 -receptor antagonists may be administered simultaneously with or 12 hours apart from ledipasvir and sofosbuvir at a dose that does not exceed doses comparable to famotidine 40 mg twice daily.

H 2 -receptor antagonists These interactions have been studied in healthy adults.