التداخل بين ليوبروليد وميثيل تستوستيرون

Tumor Flare: Increased serum testosterone (~ 50% above baseline) may occur when initiating treatment with LUPRON DEPOT.

Effect on QT/QTc Interval: Androgen deprivation therapy may prolong the QT interval.

Tumor Flare Initially, LUPRON DEPOT, like other GnRH agonists, causes increases in serum levels of testosterone to approximately 50% above baseline during the first weeks of treatment.

Effect on QT/QTc Interval Androgen deprivation therapy may prolong the QT/QTc interval.

Providers should consider whether the benefits of androgen deprivation therapy outweigh the potential risks in patients with congenital long QT syndrome, congestive heart failure, frequent electrolyte abnormalities, and in patients taking drugs known to prolong the QT interval.