التداخل بين ليوبروليد وتستوستيرون

Tumor Flare: Increased serum testosterone (~ 50% above baseline) may occur when initiating treatment with LUPRON DEPOT.

Tumor Flare Initially, LUPRON DEPOT, like other GnRH agonists, causes increases in serum levels of testosterone to approximately 50% above baseline during the first weeks of treatment.

Laboratory Tests Monitor serum levels of testosterone following injection of LUPRON DEPOT 7.5 mg for 1-month administration, 22.5 mg for 3-month administration, 30 mg for 4-month administration, or 45 mg for 6-month administration.

In the majority of patients, testosterone levels increased above baseline, and then declined thereafter to castrate levels (< 50 ng/dL) within four weeks. [see Clinical Studies ( 14 ) and Adverse Reactions ( 6 ) ] .

Effect on QT/QTc Interval: Androgen deprivation therapy may prolong the QT interval.