التداخل بين ليفودوبا وسابروبترين

Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status.

Monitor patients who are receiving levodopa for changes in neurological status during treatment with KUVAN [see Drug Interactions ( 7 )] .

Table 4: Clinically Relevant Drug Interactions Levodopa Clinical Impact Sapropterin dihydrochloride may increase the availability of tyrosine, a precursor of levodopa.

Neurologic events were reported postmarketing in patients receiving sapropterin and levodopa concomitantly for a non-PKU indication [see Warnings and Precautions ( 5.5 )] .

Interaction with Levodopa In a 10-year post-marketing safety surveillance program for a non-PKU indication using another sapropterin product, 3 patients with underlying neurological disorders experienced seizures, exacerbation of seizures, over-stimulation, and irritability during co-administration of levodopa and sapropterin.