التداخل بين ليفوفلوكساسين ووارفارين

Warfarin Effect may be enhanced.

However, there have been reports during the post-marketing experience in patients that Levofloxacin in 5% Dextrose Injection enhances the effects of warfarin.

Elevations of the prothrombin time in the setting of concurrent warfarin and Levofloxacin in 5% Dextrose Injection use have been associated with episodes of bleeding.

Prothrombin time, International Normalized Ratio (INR), or other suitable anticoagulation tests should be closely monitored if Levofloxacin in 5% Dextrose Injection is administered concomitantly with warfarin.

Similarly, no apparent effect of warfarin on levofloxacin absorption and disposition was observed.