التداخل بين ليفونورجيستريل وإيثينيل إستراديول وليفوثيروكسين وليوثيرونين

The dose of replacement thyroid hormone or cortisol therapy may need to be increased.

Thyroid Hormone Replacement Therapy or Corticosteroid Replacement Therapy Clinical effect Concomitant use of CHCs with thyroid hormone replacement therapy or corticosteroid replacement therapy may increase systemic exposure of thyroid-binding and cortisol-binding globulin [see Warnings and Precautions (5.11) ].

Prevention or management The dose of replacement thyroid hormone or cortisol therapy may need to be increased.

Estrogen, Oral Contraceptives — Estrogens tend to increase serum thyroxine-binding globulin (TBg).

In a patient with a nonfunctioning thyroid gland who is receiving thyroid replacement therapy, free levothyroxine may be decreased when estrogens are started thus increasing thyroid requirements.

Therefore, patients without a functioning thyroid gland who are on thyroid replacement therapy may need to increase their thyroid dose if estrogens or estrogen-containing oral contraceptives are given.