التداخل بين ليفوثيروكسين وليوثيرونين ووارفارين

Drug Interactions Oral Anticoagulants — Thyroid hormones appear to increase catabolism of vitamin K-dependent clotting factors.

If oral anticoagulants are also being given, compensatory increases in clotting factor synthesis are impaired.

If a patient is truly hypothyroid, it is likely that a reduction in anticoagulant dosage will be required.

No special precautions appear to be necessary when oral anticoagulant therapy is begun in a patient already stabilized on maintenance thyroid replacement therapy.

Hypothyroidism decreases and hyperthyroidism increases the sensitivity to oral anticoagulants.