التداخل بين ليفوثيروكسين وفينوباربيتال

Drug or Drug Class Effect Phenobarbital Rifampin Phenobarbital has been shown to reduce the response to thyroxine.

Phenobarbital increases L-thyroxine metabolism by inducing uridine 5’-diphospho-glucuronosyltransferase (UGT) and leads to a lower T4 serum levels.

Changes in thyroid status may occur if barbiturates are added or withdrawn from patients being treated for hypothyroidism.