التداخل بين ميتفورمين وتروسبيوم

Concomitant use with metformin immediate release tablets reduced exposure and peak concentration of trospium.

Metformin Co-administration of 500 mg metformin immediate release tablets twice daily reduced the steady-state systemic exposure of trospium by approximately 29% for mean AUC (0-24) and by 34% for mean C max .

The effect of metformin at higher doses on trospium PK is unknown [see Clinical Pharmacology ( 12.3 )].

The steady-state pharmacokinetics of metformin were comparable when administered with or without 60 mg trospium chloride extended-release capsules once daily under fasted condition.