التداخل بين ميكسيليتين وبنتوكسيفيلين

Concomitant administration of strong CYP1A2 inhibitors (including e.g., ciprofloxacin or fluvoxamine) may increase the exposure to pentoxifylline (see ADVERSE REACTIONS).

Pentoxifylline extended-release tablets have been used concurrently with antihypertensive drugs, beta blockers, digitalis, diuretics, and antiarrhythmics, without observed problems.

Concurrent use of mexiletine and theophylline may lead to increased plasma theophylline levels.

One controlled study in eight normal subjects showed a 72% mean increase (range 35 to 136%) in plasma theophylline levels.

If mexiletine and theophylline are to be used concurrently, theophylline blood levels should be monitored, particularly when the mexiletine dose is changed.

An appropriate adjustment in theophylline dose should be considered.

Theophylline plasma levels returned to pre-mexiletine values within 48 hours after discontinuing mexiletine.