التداخل بين ميدازولام وبوساكونازول

Cytochrome P450-3A4 Inhibitors: May result in prolonged sedation due to decreased plasma clearance of midazolam.

Cytochrome P450-3A4 Inhibitors Concomitant administration with drugs that are known to inhibit the P450-3A4 enzyme system, such as cimetidine (not ranitidine), erythromycin, diltiazem, verapamil, ketoconazole and itraconazole, may result in prolonged sedation due to a decrease in plasma clearance of midazolam.

Concomitant Use with Midazolam : Noxafil can prolong hypnotic/sedative effects.

Midazolam Toxicity Concomitant administration of Noxafil with midazolam increases the midazolam plasma concentrations by approximately 5-fold.

Increased plasma midazolam concentrations could potentiate and prolong hypnotic and sedative effects.

Monitor patients and benzodiazepine receptor antagonists should be available.

Patients must be monitored closely for adverse effects associated with high plasma concentrations of midazolam and benzodiazepine receptor antagonists must be available to reverse these effects [see Drug Interactions (7.2) and Clinical Pharmacology (12.3) ] .