التداخل بين بيتافاستاتين وريفامبيسين

Decrease exposure Selective 5-HT 3 Receptor Antagonists Ondansetron Decrease exposure Statins Metabolized by CYP3A4 Simvastatin Decrease exposure Thiazolidinediones Rosiglitazone Decrease AUC by 66% Tricyclic Antidepressants Nortriptyline A tuberculosis treatment regimen including rifampin (600 mg/day), isoniazid (300 mg/day), pyrazinamide (500 mg 3× per day),…

There are LIVALO dosage restrictions for patients taking erythromycin or rifampin [see Dosage and Administration (2.4) ].

Rifampin Clinical Impact: Rifampin significantly increases peak pitavastatin exposure and increases the risk of myopathy and rhabdomyolysis .

Intervention: In patients taking rifampin, do not exceed LIVALO 2 mg once daily [see Dosage and Administration (2.4) ].