التداخل بين بروبينيسيد وسالسالات

In patients on probenecid the use of salicylates in either small or large doses is contraindicated because it antagonizes the uricosuric action of probenecid.

In patients on probenecid who require a mild analgesic agent the use of acetaminophen rather than small doses of salicylates would be preferred.

The biphasic action of salicylates in the renal tubules accounts for the so-called “paradoxical effect” of uricosuric agents.

The use of salicylates antagonizes the uricosuric action of probenecid (see WARNINGS ).