التداخل بين بروبرانولول وزيلوتون

Impact of Other Drugs on Propranolol CYP2D6, CYP1A2 and CYP2C19 Inhibitors: CYP2D6 inhibitors (e.g. bupropion, fluoxetine, paroxetine, quinidine), CYP1A2 inhibitors (e.g., ciprofloxacin, enoxamine, fluvoxamine) and CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) increase exposure to propranolol when co-administered with INNOPRAN XL.

Propranolol Co-administration of zileuton immediate-release tablets and propranolol results in a significant increase in propranolol concentrations.

Administration of a single 80 mg dose of propranolol in 16 healthy male subjects who received zileuton immediate-release tablets 600 mg every 6 hours for 5 days resulted in a 42% decrease in propranolol clearance.

This resulted in an increase in propranolol C max , AUC, and elimination half-life by 52%, 104%, and 25%, respectively.

Patients concomitantly on Zileuton Extended-Release Tablets and propranolol should be closely monitored and the dose of propranolol reduced as necessary.

Zileuton increases propranolol levels and beta-blocker activity.