التداخل بين رابيبرازول وريلبيفيرين

PPIs, including ACIPHEX, are contraindicated with rilpivirine-containing products [see Drug Interactions (7) ] .

PPIs, including ACIPHEX delayed-release tablets, are contraindicated in patients receiving rilpivirine-containing products ( 4 , 7 ).

Intervention: Rilpivirine-containing products : Concomitant use with ACIPHEX delayed-release tablets is contraindicated [see Contraindications (4) ] .

Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with rabeprazole may reduce antiviral effect and promote the development of drug resistance.

Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with rabeprazole may increase toxicity.

John's wort ( Hypericum perforatum ) Proton Pump Inhibitors e.g., Esomeprazole Lansoprazole Omeprazole Pantoprazole Rabeprazole Potential for significant decreases in rilpivirine plasma concentrations due to gastric pH increase, which may result in loss of virologic response.

Proton Pump Inhibitors: e.g., esomeprazole lansoprazole omeprazole pantoprazole rabeprazole ↓ rilpivirine Coadministration is contraindicated with EDURANT or EDURANT PED [see Contraindications (4) ] .