التداخل بين ريفامبيسين وتاموكسيفين

…Antiarrhythmics Disopyramide Decrease exposure Mexiletine Decrease exposure Quinidine Decrease exposure Propafenone Decrease AUC by 50%-67% Tocainide Decrease exposure Antiestrogens Tamoxifen Decrease AUC by 86% Toremifene Decrease steady state concentrations of toremifene in serum Antithrombotic Agents Clopidogrel Prevention or Management: Concomitant use of clopidogrel…

Inducers of CYP3A4 Strong CYP3A4 inducers should not be used with tamoxifen.

Strong CYP3A4 inducers (e.g., rifampin) reduce tamoxifen AUC and C max [see Clinical Pharmacology (12.3) ] .