التداخل بين سيتاغليبتين وميتفورمين وزونيساميد

Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (e.g., carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, hepatic…

Table 4 presents clinically significant drug interactions with JANUMET XR: Table 4: Clinically Significant Drug Interactions with JANUMET XR Carbonic Anhydrase Inhibitors Clinical Impact: Carbonic anhydrase inhibitors frequently cause a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.

Carbonic anhydrase inhibitors may increase risk of lactic acidosis.

Examples: Topiramate, zonisamide, acetazolamide or dichlorphenamide.