التداخل بين حمض الفالبرويك ووارفارين

Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with valproic acid oral solution (7.2)

Warfarin In an in vitro study, valproate increased the unbound fraction of warfarin by up to 32.6%.

The therapeutic relevance of this is unknown; however, coagulation tests should be monitored if valproate therapy is instituted in patients taking anticoagulants.