Interaction Checker

Ambrisentan interactions

Ambrisentan (Letairis) has 34 documented interactions across the FDA labels and fact sheets we index: 0 major, 2 moderate, 32 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

What Ambrisentan looks like

All 18 versions
Ambrisentan 10 mg tablet: red, oval, 10 mm, imprinted GSI on one side and 10 on the other.
GSI / 10
10 mg · red · oval · 10 mm
Gilead Sciences
Ambrisentan 5 mg tablet: pink, square, 7 mm, imprinted GSI on one side and 5 on the other.
GSI / 5
5 mg · pink · square · 7 mm
Gilead Sciences
Ambrisentan 5 mg tablet: pink, round, 8 mm, imprinted 1179.
1179
5 mg · pink · round · 8 mm
Zydus Pharmaceuticals
Ambrisentan 10 mg tablet: white, oval, 10 mm, imprinted 1180.
1180
10 mg · white · oval · 10 mm
Zydus Pharmaceuticals

Renderings from the FDA labels' product listings: color, shape, size, and imprint. 18 documented versions from 11 labelers.

Interactions from the label

Moderate interactions (2)

  • CyclosporineimmunosuppressantModerate

    Multiple dose coadministration of ambrisentan and cyclosporine resulted in an approximately 2-fold increase in ambrisentan exposure in healthy volunteers; therefore, limit the dose of ambrisentan to 5 mg once daily when coadministered with cyclosporine [see Clinical Pharmacology (12.3) ] . (Ambrisentan label, Drug interactions)

  • LomitapideModerate

    Coadministration of lomitapide with P-gp substrates (such as aliskiren, ambrisentan, colchicine, dabigatran etexilate, digoxin, everolimus, fexofenadine, imatinib, lapatinib, maraviroc, nilotinib, posaconazole, ranolazine, saxagliptin, sirolimus, sitagliptin, talinolol, tolvaptan, topotecan) may increase the absorption of P-gp substrates. (Lomitapide label, Drug interactions)

Minor mentions (32)

  • Acetazolamidecarbonic anhydrase inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Amiloridepotassium-sparing diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Atenolol and chlorthalidonebeta blockerMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Benazepril and hydrochlorothiazideACE inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Bisoprolol and hydrochlorothiazidebeta blockerMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Bumetanideloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Chlorothiazidethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Chlorthalidonethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Enalapril and hydrochlorothiazideACE inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Eplerenonealdosterone antagonistMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Ethacrynic acidloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Fosinopril and hydrochlorothiazideACE inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Furosemideloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Hydrochlorothiazidethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Indapamidethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Lisinopril and hydrochlorothiazideACE inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Metolazonethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Metoprolol and hydrochlorothiazidebeta blockerMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Quinapril and hydrochlorothiazideACE inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Spironolactonealdosterone antagonistMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • TadalafilPDE5 inhibitorMinor

    Peripheral edema/fluid retention is more common with Letairis plus tadalafil than with Letairis or tadalafil alone. (Ambrisentan label, Warnings and precautions)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Torsemideloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Triamterenepotassium-sparing diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.