Interaction Checker

Ambrisentan interactions

Ambrisentan (Letairis) has 21 documented interactions across the FDA labels and fact sheets we index: 0 major, 1 moderate, 20 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Moderate interactions (1)

  • CyclosporineimmunosuppressantModerate

    Multiple dose coadministration of ambrisentan and cyclosporine resulted in an approximately 2-fold increase in ambrisentan exposure in healthy volunteers; therefore, limit the dose of ambrisentan to 5 mg once daily when coadministered with cyclosporine [see Clinical Pharmacology (12.3) ] . (Ambrisentan label, Drug interactions)

Minor mentions (20)

  • Acetazolamidecarbonic anhydrase inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Amiloridepotassium-sparing diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Bisoprolol and hydrochlorothiazidebeta blockerMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Bumetanideloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Chlorthalidonethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Eplerenonealdosterone antagonistMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Ethacrynic acidloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Furosemideloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Hydrochlorothiazidethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Indapamidethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Lisinopril and hydrochlorothiazideACE inhibitorMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Metolazonethiazide diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Spironolactonealdosterone antagonistMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • TadalafilPDE5 inhibitorMinor

    Peripheral edema/fluid retention is more common with Letairis plus tadalafil than with Letairis or tadalafil alone. (Ambrisentan label, Warnings and precautions)

  • Torsemideloop diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Triamterenepotassium-sparing diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticMinor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Patients required intervention with a diuretic, fluid management, or, in some cases, hospitalization for decompensating heart failure. (Ambrisentan label, Warnings and precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.