Ambrisentan and Tadalafil interaction
Ambrisentan and Tadalafil: the Ambrisentan prescribing label mentions this combination without an instruction to avoid it or change the dose.
Minor
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Ambrisentan (Letairis) label · effective 2026-06-22
Minor
Peripheral edema/fluid retention is more common with Letairis plus tadalafil than with Letairis or tadalafil alone.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.