Amoxicillin interactions
Amoxicillin (Amoxil, Moxatag), a penicillin antibiotic has 66 documented interactions across the FDA labels and fact sheets we index: 19 major, 33 moderate, 12 minor, and 2 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.
Major interactions (19)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
• Cardiovascular Death: Some observational studies have shown an approximately two-fold increased short-term potential risk of acute cardiovascular death in adults exposed to azithromycin relative to other antibacterial drugs, including amoxicillin. (Azithromycin label, Warnings and precautions)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
Avoid co-administration of tetracyclines with penicillin. (Doxycycline label, Drug interactions)
• For information about contraindications of amoxicillin and clarithromycin, indicated in combination with NEXIUM for H. pylori eradication to reduce the risk of duodenal ulcer recurrence, refer to the Contraindications section of the respective prescribing information. (Esomeprazole label, Contraindications)
For information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with PREVACID or PREVACID SoluTab, refer to the Contraindications section of their prescribing information. (Lansoprazole label, Contraindications)
Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (Minocycline label, Drug interactions)
• For information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with PRILOSEC, refer to the CONTRAINDICATIONS section of their package inserts. (Omeprazole label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
For information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with ACIPHEX delayed-release tablets, refer to the Contraindications section of their package inserts. (Rabeprazole label, Contraindications)
Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)
Moderate interactions (33)
Co-administration with allopurinol increases the risk of rash. (Amoxicillin label, Drug interactions)
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
- Bisoprolol and hydrochlorothiazidebeta blockerModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Bisoprolol and hydrochlorothiazide label, Warnings)
- Cholestyraminebile acid sequestrantModerate
Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)
- Conjugated estrogensestrogenModerate
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
- DabigatrananticoagulantModerate
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
- Drospirenone and ethinyl estradioloral contraceptiveModerate
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
- EdoxabananticoagulantModerate
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
- EnoxaparinanticoagulantModerate
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
Following administration of ampicillin or amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted. (Amoxicillin label, Drug interactions)
- FondaparinuxanticoagulantModerate
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
- HeparinanticoagulantModerate
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Hydrochlorothiazide label, Warnings and precautions)
- LeflunomideimmunosuppressantModerate
In patients taking ARAVA, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Leflunomide label, Drug interactions)
- LevonorgestrelprogestinModerate
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
- Lisinopril and hydrochlorothiazideACE inhibitorModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Lisinopril and hydrochlorothiazide label, Warnings)
- Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Losartan and hydrochlorothiazide label, Warnings and precautions)
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
- MegestrolprogestinModerate
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
Effect of Other Drugs on XATMEP Oral Antibiotics Penicillins may reduce the renal clearance of methotrexate; increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with methotrexate. (Methotrexate label, Drug interactions)
- MycophenolateimmunosuppressantModerate
Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing MYHIBBIN… (Mycophenolate label, Drug interactions)
- NorethindroneprogestinModerate
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
- Norgestimate and ethinyl estradioloral contraceptiveModerate
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
- ProgesteroneprogestinModerate
Amoxicillin may reduce the efficacy of oral contraceptives. (Amoxicillin label, Drug interactions)
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
- Spironolactone and hydrochlorothiazidealdosterone antagonistModerate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Spironolactone and hydrochlorothiazide label, Warnings)
- TeriflunomideimmunosuppressantModerate
In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (Teriflunomide label, Drug interactions)
- Triamterenepotassium-sparing diureticModerate
…from blood bank (may contain up to 30 mEq of potassium per liter of plasma or up to 65 mEq per liter of whole blood when stored for more than 10 days); low-salt milk (may contain up to 60 mEq of potassium per liter); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium). (Triamterene label, Drug interactions)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Triamterene and hydrochlorothiazide label, Warnings)
- Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (Valsartan and hydrochlorothiazide label, Warnings and precautions)
Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (Amoxicillin label, Drug interactions)
Minor mentions (12)
- Acetazolamidecarbonic anhydrase inhibitorMinor
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
- Dorzolamidecarbonic anhydrase inhibitorMinor
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
- Dorzolamide and timololcarbonic anhydrase inhibitorMinor
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
- Fidaxomicinmacrolide antibioticMinor
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
- NeomycinaminoglycosideMinor
Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. (Neomycin label, Drug interactions)
- Raloxifeneselective estrogen receptor modulatorMinor
Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (Raloxifene label, Drug interactions)
- Silver sulfadiazinesulfonamideMinor
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
- SulfasalazinesulfonamideMinor
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
Other Antibacterials Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. (Amoxicillin label, Drug interactions)
No significant interaction reported (2)
Drugs Without Clinically Significant Drug Interaction with TAMIFLU No dose adjustments are needed for either oseltamivir or the concomitant drug when coadministering oseltamivir with amoxicillin, acetaminophen, aspirin, cimetidine, antacids (magnesium and aluminum hydroxides and calcium carbonates), rimantadine, amantadine, or warfarin [see Clinical Pharmacology… (Oseltamivir label, Drug interactions)
…have been documented not to interact with theophylline or drugs that produce no clinically significant interaction with theophylline.* albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without methylprednisolone sulbactam metronidazole atenolol metoprolol azithromycin nadolol caffeine, dietary ingestion nifedipine… (Theophylline label, Drug interactions)
Check Amoxicillin against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.