Amoxicillin and Probenecid interaction
Amoxicillin and Probenecid: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Amoxicillin label · effective 2026-07-07
Probenecid Probenecid decreases the renal tubular secretion of amoxicillin.
Concurrent use of amoxicillin and probenecid may result in increased and prolonged blood levels of amoxicillin.
From the Probenecid label · effective 2026-04-29
Drug Interactions When probenecid is used to elevate plasma concentrations of penicillin or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug.
In the case of penicillin or other beta-lactams, psychic disturbances have been reported.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.