Cefixime interactions
Cefixime (Suprax), a cephalosporin has 50 documented interactions across the FDA labels and fact sheets we index: 23 major, 25 moderate, 2 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.
What Cefixime looks like
All 5 versionsRenderings from the FDA labels' product listings: color, shape, size, and imprint. 5 documented versions from 5 labelers.
Interactions from the label
Major interactions (23)
AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)
History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AUGMENTIN or to other beta‑lactams (e.g., penicillins or cephalosporins). (Amoxicillin and clavulanate label, Contraindications)
CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Ampicillin and sulbactam label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)
INVANZ is contraindicated in patients with known hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams. (Ertapenem label, Contraindications)
Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (Imipenem and cilastatin label, Warnings and precautions)
WARNINGS Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving beta-lactam antibacterial drugs. (Nafcillin label, Warnings)
Piperacillin and Tazobactam for Injection and Sodium Chloride Injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or betalactamase inhibitors. (Piperacillin and tazobactam label, Contraindications)
Moderate interactions (25)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Use caution when CAYSTON is administered to patients with a known allergic reaction to beta-lactams. (Aztreonam label, Warnings and precautions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations. (Cefixime label, Drug interactions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (Ethacrynic acid label, Drug interactions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Cephalosporin Furosemide can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment. (Furosemide label, Drug interactions)
Increased nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins. (Gentamicin label, Drug interactions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing mycophenolate… (Mycophenolate label, Drug interactions)
If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)
If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)
If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)
Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated. (Cefixime label, Warnings and precautions)
- ProbenecidModerate
Drug Interactions When probenecid is used to elevate plasma concentrations of penicillin or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Probenecid label, Drug interactions)
- Probenecid and colchicineModerate
DRUG INTERACTIONS When probenecid is used to elevate plasma concentrations of penicillin, or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug. (Probenecid and colchicine label, Drug interactions)
- ProtamineModerate
Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (Protamine label, Precautions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated. (Cefixime label, Warnings and precautions)
Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)
Minor mentions (2)
Before initiating therapy with Meropenem for injection, it is important to inquire about previous hypersensitivity reactions to penicillins, cephalosporins, other β-lactams, and other allergens. (Meropenem label, Warnings and precautions)
Drug/Laboratory Test Interactions A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not with those using nitroferricyanide. (Cefixime label, Drug interactions)
Check Cefixime against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.



