Cefixime interactions

Cefixime (Suprax), a cephalosporin has 26 documented interactions across the FDA labels and fact sheets we index: 8 major, 18 moderate, 0 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (8)

  • Amoxicillinpenicillin antibioticMajor

    AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Amoxicillin label, Contraindications)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AUGMENTIN or to other beta‑lactams (e.g., penicillins or cephalosporins). (Amoxicillin and clavulanate label, Contraindications)

  • Ampicillinpenicillin antibioticMajor

    CONTRAINDICATIONS The use of Ampicillin is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin or to other beta-lactam antibacterial drugs. (Ampicillin label, Contraindications)

  • CefadroxilcephalosporinMajor

    Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)

  • CefdinircephalosporinMajor

    Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)

  • CefpodoximecephalosporinMajor

    Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)

  • CefuroximecephalosporinMajor

    Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)

  • CephalexincephalosporinMajor

    Contraindicated in patients with known allergy to cefixime or other cephalosporins. (Cefixime label, Contraindications)

Moderate interactions (18)

  • ApixabananticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

  • CarbamazepineanticonvulsantModerate

    Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations. (Cefixime label, Drug interactions)

  • DabigatrananticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

  • Dicloxacillinpenicillin antibioticModerate

    If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)

  • EdoxabananticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

  • EnoxaparinanticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

  • Ethacrynic acidloop diureticModerate

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (Ethacrynic acid label, Drug interactions)

  • FondaparinuxanticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

  • Furosemideloop diureticModerate

    Cephalosporin Furosemide can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment. (Furosemide label, Drug interactions)

  • GentamicinaminoglycosideModerate

    Increased nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins. (Gentamicin label, Drug interactions)

  • HeparinanticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

  • MycophenolateimmunosuppressantModerate

    Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing MYHIBBIN… (Mycophenolate label, Drug interactions)

  • Penicillin Gpenicillin antibioticModerate

    If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)

  • Penicillin Vpenicillin antibioticModerate

    If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibacterial drugs has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. (Cefixime label, Warnings and precautions)

  • Phytonadione (vitamin K1)vitamin KModerate

    Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated. (Cefixime label, Warnings and precautions)

  • RivaroxabananticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

  • Vitamin KVitamin and mineralModerate

    Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated. (Cefixime label, Warnings and precautions)

  • WarfarinanticoagulantModerate

    Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (Cefixime label, Warnings and precautions)

Check Cefixime against everything you take. Add your full list; every pair is checked at once.

Open in the checker

Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.