Cefixime and Cephalexin interaction
Cefixime and Cephalexin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Cefixime label · effective 2026-08-05
Contraindicated in patients with known allergy to cefixime or other cephalosporins.
Cefixime is contraindicated in patients with known allergy to cefixime or other cephalosporins.
A false positive direct Coombs test has been reported during treatment with other cephalosporins; therefore, it should be recognized that a positive Coombs test may be due to the drug.
From the Cephalexin label · effective 2026-03-25
Cephalexin is contraindicated in patients with known hypersensitivity to cephalexin or other members of the cephalosporin class of antibacterial drugs.
Patients with known hypersensitivity to cephalexin or other members of the cephalosporin class of antibacterial drugs.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.