Interaction Checker

Cefuroxime interactions

Cefuroxime (Ceftin), a cephalosporin has 23 documented interactions across the FDA labels and fact sheets we index: 17 major, 4 moderate, 2 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (17)

  • Amoxicillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Ampicillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefadroxilcephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefdinircephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefiximecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefpodoximecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CephalexincephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Dexlansoprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Dicloxacillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Esomeprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Lansoprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Omeprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Pantoprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Penicillin Gpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Penicillin Vpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Rabeprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

Moderate interactions (4)

  • Ethacrynic acidloop diureticModerate

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (Ethacrynic acid label, Drug interactions)

  • Furosemideloop diureticModerate

    Cephalosporin Furosemide can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment. (Furosemide label, Drug interactions)

  • GentamicinaminoglycosideModerate

    Increased nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins. (Gentamicin label, Drug interactions)

  • MycophenolateimmunosuppressantModerate

    Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing MYHIBBIN… (Mycophenolate label, Drug interactions)

Minor mentions (2)

  • Antacids (Tums, Maalox, Mylanta)OTC productMinor

    Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids. (Cefuroxime label, Drug interactions)

  • Sodium bicarbonateantacidMinor

    Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids. (Cefuroxime label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.