Cefuroxime interactions
Cefuroxime (Ceftin), a cephalosporin has 47 documented interactions across the FDA labels and fact sheets we index: 37 major, 6 moderate, 3 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.
What Cefuroxime looks like
All 9 versionsRenderings from the FDA labels' product listings: color, shape, size, and imprint. 9 documented versions from 9 labelers.
Interactions from the label
Major interactions (37)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
INVANZ is contraindicated in patients with known hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams. (Ertapenem label, Contraindications)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (Imipenem and cilastatin label, Warnings and precautions)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)
- ProbenecidMajor
Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. (Cefuroxime label, Drug interactions)
Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. (Cefuroxime label, Drug interactions)
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)
Moderate interactions (6)
Use caution when CAYSTON is administered to patients with a known allergic reaction to beta-lactams. (Aztreonam label, Warnings and precautions)
Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (Ethacrynic acid label, Drug interactions)
Cephalosporin Furosemide can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment. (Furosemide label, Drug interactions)
Increased nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins. (Gentamicin label, Drug interactions)
Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing mycophenolate… (Mycophenolate label, Drug interactions)
- ProtamineModerate
Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (Protamine label, Precautions)
Minor mentions (3)
Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids. (Cefuroxime label, Drug interactions)
Before initiating therapy with Meropenem for injection, it is important to inquire about previous hypersensitivity reactions to penicillins, cephalosporins, other β-lactams, and other allergens. (Meropenem label, Warnings and precautions)
Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids. (Cefuroxime label, Drug interactions)
No significant interaction reported (1)
There was no effect on neostigmine action on rocuronium reversal by cefuroxime, metronidazole, cefuroxime or metronidazole. (Neostigmine label, Drug interactions)
Check Cefuroxime against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.



