Cefuroxime interactions

Cefuroxime (Ceftin), a cephalosporin has 47 documented interactions across the FDA labels and fact sheets we index: 37 major, 6 moderate, 3 minor, and 1 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

What Cefuroxime looks like

All 9 versions
Cefuroxime 500 mg tablet: blue, capsule-shaped, 19 mm, imprinted 203.
203
500 mg · blue · capsule-shaped · 19 mm
Redpharm Drug
Cefuroxime 250 mg tablet: white, oval, 16 mm, imprinted A33.
A33
250 mg · white · oval · 16 mm
Redpharm Drug
Cefuroxime 500 mg tablet: white, oval, 20 mm, imprinted A34.
A34
500 mg · white · oval · 20 mm
Redpharm Drug
Cefuroxime 250 mg tablet: blue, capsule-shaped, 15 mm, imprinted 204.
204
250 mg · blue · capsule-shaped · 15 mm
Ascend

Renderings from the FDA labels' product listings: color, shape, size, and imprint. 9 documented versions from 9 labelers.

Interactions from the label

Major interactions (37)

  • Amoxicillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Ampicillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Ampicillin and sulbactampenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefaclorcephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefadroxilcephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefazolincephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefdinircephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefepimecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefiximecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefotaximecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefotetancephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefoxitincephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefpodoximecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CefprozilcephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CeftarolinecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CeftazidimecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CeftriaxonecephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • CephalexincephalosporinMajor

    Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactams (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Dexlansoprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Dicloxacillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • ErtapenemantibioticMajor

    INVANZ is contraindicated in patients with known hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams. (Ertapenem label, Contraindications)

  • Esomeprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (Imipenem and cilastatin label, Warnings and precautions)

  • Lansoprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Nafcillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Omeprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Omeprazole and sodium bicarbonateproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Oxacillinpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Pantoprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

  • Penicillin Gpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Penicillin Vpenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Piperacillin and tazobactampenicillin antibioticMajor

    Cefuroxime axetil is contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (Cefuroxime label, Contraindications)

  • Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. (Cefuroxime label, Drug interactions)

  • Coadministration with probenecid increases systemic exposure to cefuroxime axetil and is therefore not recommended. (Cefuroxime label, Drug interactions)

  • Rabeprazoleproton pump inhibitorMajor

    Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided. (Cefuroxime label, Drug interactions)

Moderate interactions (6)

  • AztreonamantibioticModerate

    Use caution when CAYSTON is administered to patients with a known allergic reaction to beta-lactams. (Aztreonam label, Warnings and precautions)

  • Ethacrynic acidloop diureticModerate

    Ethacrynic acid may increase the ototoxic potential of other drugs such as aminoglycoside and some cephalosporin antibiotics. (Ethacrynic acid label, Drug interactions)

  • Furosemideloop diureticModerate

    Cephalosporin Furosemide can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment. (Furosemide label, Drug interactions)

  • GentamicinaminoglycosideModerate

    Increased nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporins. (Gentamicin label, Drug interactions)

  • MycophenolateimmunosuppressantModerate

    Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing mycophenolate… (Mycophenolate label, Drug interactions)

  • ProtamineModerate

    Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (Protamine label, Precautions)

Minor mentions (3)

  • Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids. (Cefuroxime label, Drug interactions)

  • MeropenemantibioticMinor

    Before initiating therapy with Meropenem for injection, it is important to inquire about previous hypersensitivity reactions to penicillins, cephalosporins, other β-lactams, and other allergens. (Meropenem label, Warnings and precautions)

  • Sodium bicarbonateantacidMinor

    Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids. (Cefuroxime label, Drug interactions)

No significant interaction reported (1)

  • Neostigminecholinesterase inhibitorNo interaction

    There was no effect on neostigmine action on rocuronium reversal by cefuroxime, metronidazole, cefuroxime or metronidazole. (Neostigmine label, Drug interactions)

Check Cefuroxime against everything you take. Add your full list; every pair is checked at once.

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.