Cefuroxime and Omeprazole and sodium bicarbonate interaction
Cefuroxime and Omeprazole and sodium bicarbonate: the Cefuroxime prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Cefuroxime (Cefuroxime axetil) label · effective 2026-01-16
Histamine-2 (H 2 ) antagonists and proton pump inhibitors should be avoided.
Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.