Interaction Checker

Corticotropin interactions

Corticotropin (Acthar, Purified Cortrophin Gel) has 56 documented interactions across the FDA labels and fact sheets we index: 0 major, 3 moderate, 53 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Moderate interactions (3)

  • Amphotericin BantifungalModerate

    Corticosteroids and Corticotropin (ACTH) Concurrent use of corticosteroids and ACTH may potentiate hypokalemia, which could predispose the patient to cardiac dysfunction. (Amphotericin B label, Drug interactions)

  • MitotaneCYP3A4 inducerModerate

    Due to increased steroid clearance and increase of steroid-binding protein, high-dose replacement therapy may be required and free cortisol and corticotropin (ACTH) should be monitored to adapt the systemic corticosteroids. (Mitotane label, Warnings and precautions)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    Other Considerations Concurrent use of hydrochlorothiazide with amphotericin B or corticosteroids or corticotropin (ACTH) may intensify electrolyte imbalance, particularly hypokalemia, although the presence of triamterene minimizes the hypokalemic effect. (Triamterene and hydrochlorothiazide label, Drug interactions)

Minor mentions (53)

  • Acetazolamidecarbonic anhydrase inhibitorMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Amiloridepotassium-sparing diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Atenolol and chlorthalidonebeta blockerMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Azelastine and fluticasoneantihistamineMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • BeclomethasonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Benazepril and hydrochlorothiazideACE inhibitorMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • BetamethasonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Bisoprolol and hydrochlorothiazidebeta blockerMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • BudesonidecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Budesonide and formoterolcorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Bumetanideloop diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Chlorothiazidethiazide diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Chlorthalidonethiazide diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • CiclesonidecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • ClobetasolcorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • DeflazacortcorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • DesonidecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • DexamethasonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Enalapril and hydrochlorothiazideACE inhibitorMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Eplerenonealdosterone antagonistMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Ethacrynic acidloop diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • FludrocortisonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • FlunisolidecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • FluocinonidecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • FluticasonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Fluticasone and salmeterolcorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Fosinopril and hydrochlorothiazideACE inhibitorMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Furosemideloop diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • HalobetasolcorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Hydrochlorothiazidethiazide diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • HydrocortisonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Indapamidethiazide diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Lisinopril and hydrochlorothiazideACE inhibitorMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • MethylprednisolonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Metolazonethiazide diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Metoprolol and hydrochlorothiazidebeta blockerMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • MometasonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Olopatadine and mometasoneantihistamineMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • PrednisolonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • PrednisonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Quinapril and hydrochlorothiazideACE inhibitorMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Spironolactonealdosterone antagonistMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Torsemideloop diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • TriamcinolonecorticosteroidMinor

    The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (Corticotropin label, Warnings and precautions)

  • Triamterenepotassium-sparing diureticMinor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Acthar Gel may accentuate the electrolyte loss associated with diuretic therapy. (Corticotropin label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.