Interaction Checker

Daunorubicin interactions

Daunorubicin (Cerubidine) has 6 documented interactions across the FDA labels and fact sheets we index: 1 major, 5 moderate, 0 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (1)

  • DoxorubicinMajor

    Daunorubicin hydrochloride should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or daunorubicin hydrochloride. (Daunorubicin label, Drug interactions)

Moderate interactions (5)

  • BortezomibModerate

    In a clinical trial, the first two patients given high-dose cytarabine (2 g/m 2 per day) by continuous infusion with daunorubicin and bortezomib for relapsed acute myelogenous leukemia died of ARDS early in the course of therapy. (Bortezomib label, Warnings and precautions)

  • CyclophosphamideimmunosuppressantModerate

    Cyclophosphamide used concurrently with daunorubicin hydrochloride may also result in increased cardiotoxicity. (Daunorubicin label, Drug interactions)

  • CyclosporineimmunosuppressantModerate

    Anthracycline Antibiotics High doses of cyclosporine (e.g., at starting intravenous dose of 16 mg/kg/day) may increase the exposure to anthracycline antibiotics (e.g., doxorubicin, mitoxantrone, daunorubicin) in cancer patients. (Cyclosporine label, Drug interactions)

  • MethotrexateimmunosuppressantModerate

    Hepatotoxic medications, such as high-dose methotrexate, may impair liver function and increase the risk of toxicity. (Daunorubicin label, Drug interactions)

  • MitoxantroneModerate

    Cardiac Effects Because of the possible danger of cardiac effects in patients previously treated with daunorubicin or doxorubicin, the benefit-to-risk ratio of mitoxantrone injection therapy in such patients should be determined before starting therapy. (Mitoxantrone label, Warnings)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.