Interaction Checker

Hyaluronidase interactions

Hyaluronidase (Hylenex, Amphadase, Vitrase) has 106 documented interactions across the FDA labels and fact sheets we index: 12 major, 78 moderate, 16 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (12)

  • Apraclonidinealpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Brimonidinealpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Brimonidine and timololalpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Clonidinealpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Dexmedetomidinealpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • EpinephrinesympathomimeticMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Guanfacinealpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Lofexidinealpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • MethyldopaantihypertensiveMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Midodrinealpha-adrenergic agonistMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • Tizanidinemuscle relaxantMajor

    • Hyaluronidase should not be used to enhance the absorption and dispersion of dopamine and/or alpha agonist drugs ( 7.2 ) (Hyaluronidase label, Drug interactions)

  • VincristineMajor

    Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis. (Vincristine label, Boxed warning)

Moderate interactions (78)

  • Articaine and epinephrinelocal anestheticModerate

    Admixture stability studies have shown that 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to the presence of sodium metabisulfite, a common additive in anesthetic products containing epinephrine. (Hyaluronidase label, Drug interactions)

  • AspirinNSAIDModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Aspirin and dipyridamoleantiplatelet agentModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • AzelastineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Azelastine and fluticasoneantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • BalsalazidesalicylateModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Bismuth subsalicylatesalicylateModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Brompheniramine, pseudoephedrine, and dextromethorphanantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Bupivacainelocal anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • Bupivacaine and epinephrinelocal anestheticModerate

    Admixture stability studies have shown that 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to the presence of sodium metabisulfite, a common additive in anesthetic products containing epinephrine. (Hyaluronidase label, Drug interactions)

  • Butalbital, aspirin, and caffeinebarbiturateModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Butalbital, aspirin, caffeine, and codeinebarbiturateModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • CarbinoxamineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • CetirizineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Chloroprocainelocal anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • ChlorpheniramineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • ClemastineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Cocainelocal anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • Conjugated estrogensestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Conjugated estrogens and bazedoxifeneestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • CyproheptadineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Desfluranegeneral anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • DesloratadineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Desogestrel and ethinyl estradioloral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • DexchlorpheniramineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • DiflunisalNSAIDModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • DimenhydrinateantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • DiphenhydramineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • DoxylamineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Doxylamine and pyridoxineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Drospirenone and ethinyl estradioloral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Esterified estrogens and methyltestosteroneestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • EstradiolestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Estradiol and dienogestoral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Estradiol and norethindroneestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Ethynodiol diacetate and ethinyl estradioloral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Etomidategeneral anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • Etonogestrel and ethinyl estradiolestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • FexofenadineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • FulvestrantestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Hydrocodone and chlorpheniramineopioidModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • HydroxyzineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Isofluranegeneral anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • KetamineCNS depressantModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • LevocetirizineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Levonorgestrel and ethinyl estradioloral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Levothyroxinethyroid hormoneModerate

    …recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed. (Hyaluronidase label, Drug interactions)

  • Levothyroxine and liothyroninethyroid hormoneModerate

    …recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed. (Hyaluronidase label, Drug interactions)

  • Lidocainelocal anestheticModerate

    Admixture stability studies have shown that 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to the presence of sodium metabisulfite, a common additive in anesthetic products containing epinephrine. (Hyaluronidase label, Drug interactions)

  • Lidocaine and epinephrinelocal anestheticModerate

    Admixture stability studies have shown that 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to the presence of sodium metabisulfite, a common additive in anesthetic products containing epinephrine. (Hyaluronidase label, Drug interactions)

  • Lidocaine and prilocainelocal anestheticModerate

    Admixture stability studies have shown that 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to the presence of sodium metabisulfite, a common additive in anesthetic products containing epinephrine. (Hyaluronidase label, Drug interactions)

  • Liothyroninethyroid hormoneModerate

    …recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed. (Hyaluronidase label, Drug interactions)

  • LoratadineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • MeclizineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Menthol and methyl salicylatesalicylateModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Mepivacainelocal anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • MesalaminesalicylateModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Methimazoleantithyroid drugModerate

    …recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed. (Hyaluronidase label, Drug interactions)

  • MethohexitalbarbiturateModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • Norelgestromin and ethinyl estradiolestrogenModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Norethindrone and ethinyl estradioloral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Norgestimate and ethinyl estradioloral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Norgestrel and ethinyl estradioloral contraceptiveModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • OlopatadineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Olopatadine and mometasoneantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Orphenadrine, aspirin, and caffeinemuscle relaxantModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Prilocaine and epinephrinelocal anestheticModerate

    Admixture stability studies have shown that 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to the presence of sodium metabisulfite, a common additive in anesthetic products containing epinephrine. (Hyaluronidase label, Drug interactions)

  • PromethazineantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Promethazine and codeineopioidModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Promethazine and dextromethorphanantihistamineModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • PropofolCNS depressantModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • Propylthiouracilantithyroid drugModerate

    …recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed. (Hyaluronidase label, Drug interactions)

  • Ropivacainelocal anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • SalsalateNSAIDModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Sevofluranegeneral anestheticModerate

    • Local anesthetics: Hyaluronidase hastens onset and shortens duration of effect, increases incidence of systemic reactions ( 7.3 ) (Hyaluronidase label, Drug interactions)

  • Sodium bicarbonateantacidModerate

    Extravasation: Prompt elevation of the area, warmth, and local injection of lidocaine or hyaluronidase are recommended to reduce the likelihood of tissue sloughing at the site. (Sodium bicarbonate label, Warnings and precautions)

  • SulfasalazinesulfonamideModerate

    • Large doses of salicylates, cortisone, adrenocorticotropic hormone (ACTH), estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect ( 7.4 ) (Hyaluronidase label, Drug interactions)

  • Teriparatidethyroid hormoneModerate

    …recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed. (Hyaluronidase label, Drug interactions)

Minor mentions (16)

  • AlprazolambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • ChlordiazepoxidebenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • Chlordiazepoxide and clidiniumbenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • ClobazambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • ClonazepambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • ClorazepatebenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • DiazepambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • EstazolambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • FlumazenilbenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • Furosemideloop diureticMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • LorazepambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • MidazolambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • OxazepambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • PhenytoinanticonvulsantMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • TemazepambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

  • TriazolambenzodiazepineMinor

    • Furosemide, the benzodiazepines and phenytoin are incompatible with hyaluronidase ( 7.1 ) (Hyaluronidase label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.