Interaction Checker

Hydroxyurea interactions

Hydroxyurea (Hydrea, Droxia, Siklos), an antimetabolite has 15 documented interactions across the FDA labels and fact sheets we index: 5 major, 8 moderate, 2 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (5)

  • Bictegravir, emtricitabine, and tenofovir alafenamideantiretroviralMajor

    Increased Toxicity with Concomitant Use of Antiretroviral Drugs Pancreatitis Pancreatitis (including fatal cases) have occurred in patients with HIV infection during therapy with hydroxyurea and didanosine, with or without stavudine. (Hydroxyurea label, Drug interactions)

  • DolutegravirantiretroviralMajor

    Increased Toxicity with Concomitant Use of Antiretroviral Drugs Pancreatitis Pancreatitis (including fatal cases) have occurred in patients with HIV infection during therapy with hydroxyurea and didanosine, with or without stavudine. (Hydroxyurea label, Drug interactions)

  • Emtricitabine and tenofovirantiretroviralMajor

    Increased Toxicity with Concomitant Use of Antiretroviral Drugs Pancreatitis Pancreatitis (including fatal cases) have occurred in patients with HIV infection during therapy with hydroxyurea and didanosine, with or without stavudine. (Hydroxyurea label, Drug interactions)

  • RitonavirantiretroviralMajor

    Increased Toxicity with Concomitant Use of Antiretroviral Drugs Pancreatitis Pancreatitis (including fatal cases) have occurred in patients with HIV infection during therapy with hydroxyurea and didanosine, with or without stavudine. (Hydroxyurea label, Drug interactions)

  • TretinoinretinoidMajor

    • Leukocytosis: Consider administering cytoreductive chemotherapy (including an anthracycline if not contraindicated or hydroxyurea) with tretinoin capsules in the setting of leukocytosis, as clinically indicated. (Tretinoin label, Warnings and precautions)

Moderate interactions (8)

  • Insulin aspartinsulinModerate

    Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (Hydroxyurea label, Warnings and precautions)

  • Insulin degludecinsulinModerate

    Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (Hydroxyurea label, Warnings and precautions)

  • Insulin detemirinsulinModerate

    Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (Hydroxyurea label, Warnings and precautions)

  • Insulin glargineinsulinModerate

    Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (Hydroxyurea label, Warnings and precautions)

  • Insulin lisproinsulinModerate

    Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (Hydroxyurea label, Warnings and precautions)

  • Insulin regular (human)insulinModerate

    Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (Hydroxyurea label, Warnings and precautions)

  • Lidocaine and prilocainelocal anestheticModerate

    …oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sufonamides Antimalarials chloroquine, primaquine Anticonvulsants Phenobarbital, phenytoin,… (Lidocaine and prilocaine label, Drug interactions)

  • TirzepatideGLP-1 receptor agonistModerate

    Hydroxyurea may falsely elevate sensor glucose results from certain continuous glucose monitoring (CGM) systems and may lead to hypoglycemia if sensor glucose results are relied upon to dose insulin. (Hydroxyurea label, Warnings and precautions)

Minor mentions (2)

  • Folic acid (folate)Vitamin and mineralMinor

    The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency. (Hydroxyurea label, Warnings and precautions)

  • Vitamin B12Vitamin and mineralMinor

    The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency. (Hydroxyurea label, Warnings and precautions)

Check Hydroxyurea against everything you take. Add your full list; every pair is checked at once.

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.