Folic acid (folate) and Hydroxyurea interaction
Folic acid (folate) and Hydroxyurea: the Hydroxyurea prescribing label mentions this combination without an instruction to avoid it or change the dose.
Mentioned, no instruction to avoid. Worth knowing; rarely a reason to change anything on its own.
What the FDA labels say
From the Hydroxyurea (Siklos) label · effective 2026-01-07
The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency.
Prophylactic administration of folic acid is recommended.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.