Leucovorin interactions

Leucovorin has 38 documented interactions across the FDA labels and fact sheets we index: 5 major, 32 moderate, 1 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (5)

CapecitabineantimetaboliteMajor
Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil. (Capecitabine label, Drug interactions)
Folic acid (folate)Vitamin and mineralMajor
VYKOURA is contraindicated in patients who have had a severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid [see Warnings and Precautions (5.1) ]. (Leucovorin label, Contraindications)
LevoleucovorinMajor
VYKOURA is contraindicated in patients who have had a severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid [see Warnings and Precautions (5.1) ]. (Leucovorin label, Contraindications)
Sulfamethoxazole and trimethoprimsulfonamideMajor
Trimethoprim-Sulfamethoxazole Avoid concomitant use of VYKOURA with trimethoprim-sulfamethoxazole . (Leucovorin label, Drug interactions)
TrimethoprimantibioticMajor
Trimethoprim-Sulfamethoxazole Avoid concomitant use of VYKOURA with trimethoprim-sulfamethoxazole . (Leucovorin label, Drug interactions)

Moderate interactions (32)

BrivaracetamanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
Cannabidiol (prescription)anticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
CarbamazepineanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
CenobamateanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
ClobazambenzodiazepineModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
ClonazepambenzodiazepineModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
Divalproex (valproate)anticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
EslicarbazepineanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
EthosuximideanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
FelbamateanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
FosphenytoinanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
GabapentinanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
LacosamideanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
LamotrigineanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
LevetiracetamanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
MethsuximideanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
OxaliplatinModerate
Hemorrhage : Increase frequency of monitoring in patients who are receiving oxaliplatin injection with fluorouracil/leucovorin and oral anticoagulants (5.9) (Oxaliplatin label, Warnings and precautions)
OxcarbazepineanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
PerampanelanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
PhenobarbitalbarbiturateModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
Phenobarbital, hyoscyamine, atropine, and scopolaminebarbiturateModerate
Folic acid in high doses may reduce the effectiveness of certain antiepileptic drugs (e.g., phenobarbital, phenytoin, and primidone) and thereby increase the frequency of seizures. (Leucovorin label, Drug interactions)
Phentermine and topiramateCNS stimulantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
PhenytoinanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
PregabalinanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
PrimidoneanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
PyrimethamineantimalarialModerate
Folinic acid (leucovorin) should be administered in a dosage of 5 to 15 mg daily (orally, IV, or IM) until normal hematopoiesis is restored. (Pyrimethamine label, Warnings)
RufinamideanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
TiagabineanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
TopiramateanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
Valproic acidanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
VigabatrinanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)
ZonisamideanticonvulsantModerate
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (Leucovorin label, Drug interactions)

Minor mentions (1)

IrinotecanMinor
5-Fluorouracil (5-FU) and Leucovorin (LV) In a phase 1 clinical study involving irinotecan, 5-fluorouracil (5-FU), and leucovorin (LV) in 26 patients with solid tumors, the disposition of irinotecan was not substantially altered when the drugs were co-administered. (Irinotecan label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.